Product Name: Anosmin Antibody
Species Reactivity: Human
Tested Applications: ELISA, ICC, IF, WB
Applications: Anosmin antibody can be used for detection of Anosmin by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin.The immunogen is located within amino acids 430 – 480 of Anosmin.
Host Species: Rabbit
Purification: Anosmin Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1158279-20-9
Product: HLCL-61 (hydrochloride)
Buffer: Anosmin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Anosmin antibody can be stored at 4 ˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Anosmin Antibody: HH1, HHA, KAL, KMS, ADMLX, WFDC19, KALIG-1, KALIG1, Anosmin-1, Adhesion molecule-like X-linked
Accession NO.: NP_000207
Protein Ino: 119395746
Official Symbol: KAL1
Geneid: 3730
Background: Anosmin Antibody: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
PubMed ID:http://aac.asm.org/content/52/12/4442.abstract
