Product Name: Androgen Receptor (phospho Tyr363) Antibody
Species Reactivity: Human, Mouse
Tested Applications: WB
Applications: Western Blot: 1:500~1:1000
User Note:
Predicted Molecular Weight: 85 kDa
Immunogen: Androgen Receptor (phospho Tyr363) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 363 (D-Y-Y (p)-N-F) derived from Human Androgen Receptor.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 33996-33-7
Product: Oxaceprol
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ANDR, Androgen receptor, Dihydrotestosterone receptor, NR3C4
Accession NO.: NP_000035.2
Protein Ino: 21322252
Official Symbol: AR
Geneid: 367
Background: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
PubMed ID:http://aac.asm.org/content/52/11/4155.abstract
