Product Name: Akirin2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, WB
Applications: Akirin2 antibody can be used for detection of Akirin2 by Western blot at 1 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2.The immunogen is located within amino acids 50 – 100 of Akirin2.
Host Species: Rabbit
Purification: Akirin2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 517-89-5
Product: Shikonin
Buffer: Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Akirin2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Akirin2 Antibody: FBI1, C6orf166, dJ486L4.2, Akirin-2
Accession NO.: EAW48578
Protein Ino: 119568963
Official Symbol: AKIRIN2
Geneid: 55122
Background: Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
PubMed ID:http://aac.asm.org/content/52/7/2653.abstract
