Product Name: Adenovirus-9 E4 Orf1 Antibody
Species Reactivity: Virus
Tested Applications: ELISA
Applications: Ad-9 E4 Orf1 antibody can detect 10ng Ad-9 E4 Orf1 peptide in ELISA at 1 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: Ad-9 E4 Orf1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the Ad-9 E4 Orf1.The immunogen is located within the last 50 amino acids of Adenovirus-9 E4 Orf1.
Host Species: Rabbit
Purification: Adenovirus-9 E4 Orf1 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 889665-86-5
Product: Epiberberine (chloride)
Buffer: Adenovirus-9 E4 Orf1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: Adenovirus-9 E4 Orf1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Adenovirus-9 E4 Orf1 Antibody: E4-ORF1, ORF1
Accession NO.: P89079
Protein Ino: 62510674
Official Symbol: E4
Geneid: 6386282
Background: Adenovirus-9 E4 Orf1 Antibody: The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.
PubMed ID:http://aac.asm.org/content/52/4/1302.abstract
