Product Name: ATP2C2 Antibody
Species Reactivity: Human, Mouse
Tested Applications: ELISA, IF, WB
Applications: ATP2C2 antibody can be used for detection of ATP2C2 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: ATP2C2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2.The immunogen is located within the first 50 amino acids of ATP2C2.
Host Species: Rabbit
Purification: ATP2C2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1351635-67-0
Product: ONO-4059 (analog)
Buffer: ATP2C2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ATP2C2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ATP2C2 Antibody: SPCA2, KIAA0703, SPCA2, Calcium-transporting ATPase type 2C member 2, ATPase 2C2
Accession NO.: NP_055676
Protein Ino: 118498343
Official Symbol: ATP2C2
Geneid: 9914
Background: ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
PubMed ID:http://aac.asm.org/content/53/7/3159.abstract
