Product Name: ASC Antibody
Species Reactivity: Human
Tested Applications: ELISA, ICC, IHC-P, WB
Applications: ASC antibody can be used for detection of ASC/TMS1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL and immunohistochemistry starting at 2.5 μg/mL..
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 25 kDa
Immunogen: ASC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human ASC .The immunogen is located within the last 50 amino acids of ASC.
Host Species: Rabbit
Purification: ASC Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 71283-80-2
Product: Fenoxaprop-P-ethyl
Buffer: ASC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ASC antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ASC Antibody: ASC protein, TMS, TMS1 antibody, CARD5, TMS-1, ASC, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, hASC
Accession NO.: BAA87339
Protein Ino: 10801602
Official Symbol: PYCARD
Geneid: 29108
Background: ASC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
PubMed ID:http://aac.asm.org/content/53/6/2283.abstract
