Product Name: AR Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 99 kDa
Immunogen: This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 amino acids from the Central region of human AR.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1161205-04-4
Product: VU0361737
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.33 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Accession NO.: P10275
Protein Ino: 113830
Official Symbol: AR
Geneid: 367
Background: The androgen receptor gene is more than 90 kb long andcodes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain.The protein functions as a steroid-hormone activated transcriptionfactor. Upon binding the hormone ligand, the receptor dissociatesfrom accessory proteins, translocates into the nucleus, dimerizes,and then stimulates transcription of androgen responsive genes.This gene contains 2 polymorphic trinucleotide repeat segments thatencode polyglutamine and polyglycine tracts in the N-terminaltransactivation domain of its protein. Expansion of thepolyglutamine tract causes spinal bulbar muscular atrophy (Kennedydisease). Mutations in this gene are also associated with completeandrogen insensitivity (CAIS). Two alternatively spliced variantsencoding distinct isoforms have been described. [provided byRefSeq].
PubMed ID:http://aac.asm.org/content/53/3/953.abstract
