Product Name: ARC Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, WB
Applications: ARC antibody can be used for detection of ARC by Western blot at 1:500 dilution. An approximately 25 kDa band can be detected.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 25 kDa
Immunogen: ARC antibody was raised against a 17 amino acid peptide near the amino terminus of human ARC.The immunogen is located within the first 50 amino acids of ARC.
Host Species: Rabbit
Purification: ARC Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 3844-45-9
Product: Brilliant Blue FCF
Buffer: ARC Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
Storage Conditions: ARC antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ARC Antibody: ARC, FCM, MYP, NOP, NOP30, ARC, Nucleolar protein 3, Apoptosis repressor with CARD, Myp
Accession NO.: NP_003937
Protein Ino: 4505419
Official Symbol: NOL3
Geneid: 8996
Background: ARC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK BCL10, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
PubMed ID:http://aac.asm.org/content/53/3/1019.abstract
