Product Name: AQP2 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IF, IHC-P, WB
Applications: AQP2 antibody can be used for detection of AQP2 by Western blot at 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 30 kDa Observed: 28 kDa
Immunogen: AQP2 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human AQP2.The immunogen is located within the last 50 amino acids of AQP2.
Host Species: Rabbit
Purification: AQP2 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1162656-22-5
Product: MCB-613
Buffer: AQP2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: AQP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AQP2 Antibody: AQP-CD, WCH-CD, Aquaporin-2, ADH water channel, AQP-2
Accession NO.: NP_000477
Protein Ino: 4502179
Official Symbol: AQP2
Geneid: 359
Background: Aquaporins are membrane proteins that serve in the transfer of water and small solutes across cellular membranes. One such aquaporin, aquaporin-2 (AQP2) is located in the kidney collecting tubule and plays a critical role in water reabsorbtion (1). AQP2 is mainly localized in intracellular vesicles but upon stimulation with anti-diuretic hormone (ADH), AQP2 is translocated to the apical plasma membrane by exocytic fusion of AQP2-bearing vesicles (2). Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus (3).
PubMed ID:http://aac.asm.org/content/53/3/1281.abstract
