Product Name: APP (Ab 668) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IF, WB
Applications: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
User Note:
Predicted Molecular Weight: 100 – 140 kDa
Immunogen: APP (Ab-668) antibody was raised against a peptide sequence around aa.666~670 (A-V-T-P-E ) derived from Human APP.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 1350456-56-2
Product: Fmoc-Val-Cit-PAB-MMAE
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, AAA
Accession NO.: NP_000475.1
Protein Ino: 4502167
Official Symbol: APP
Geneid: 351
Background: APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
PubMed ID:http://aac.asm.org/content/53/3/1287.abstract
