Product Name: APBA2 Antibody
Species Reactivity: Human
Tested Applications: ELISA, IF, IHC-P, WB
Applications: APBA2 antibody can be used for detection of APBA2 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight:
Immunogen: APBA2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APBA2.The immunogen is located within amino acids 290 – 340 of APBA2.
Host Species: Rabbit
Purification: APBA2 Antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 81485-25-8
Product: Peretinoin
Buffer: APBA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: APBA2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: APBA2 Antibody: X11L, MINT2, LIN-10, HsT16821, X11-BETA, D15S1518E, MGC:14091, X11L, Amyloid beta A4 precursor protein-binding family A member 2, Adapter protein X11beta, Mint-2
Accession NO.: NP_005494
Protein Ino: 22035550
Official Symbol: APBA2
Geneid: 321
Background: APBA2 Antibody: APBA2, a member of the X11 protein family, is a phosphotyrosine-binding domain protein and is a neuronal adapter protein that interacts with amyloid precursor protein (APP) and neuritic plaques in the brains of patients with Alzheimers disease. It stabilizes APP and inhibits production of proteolytic APP fragments including the Abeta peptide that is deposited in the brains of Alzheimers disease patients. APBA2 is believed to be involved in signal transduction processes and is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Recent reports suggest that it may also be a candidate gene for autism.
PubMed ID:http://aac.asm.org/content/53/2/716.abstract
