Product Name: AMPKa1 (Ab 487) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IHC, WB
Applications: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
User Note:
Predicted Molecular Weight: 63 kDa
Immunogen: AMPKa1 (Ab-487) antibody was raised in was raised against a peptide sequence around aa.485~489 (S-G-S-V-S) derived from Human AMPKα1.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 170846-89-6
Product: E4CPG
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AMPK, AMPKa1, MACS, PRKCSL, AAPK1, AMPK alpha-1 chain, AMPK-alpha1, HMG-CoA redustase kinase, PRKAA1
Accession NO.: NP_006242.5
Protein Ino: 94557301
Official Symbol: PRKAA1
Geneid: 5562
Background: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
PubMed ID:http://aac.asm.org/content/52/11/3883.abstract
