Product Name: ALOXE3 Antibody
Species Reactivity: Human, Mouse
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 81 kDa
Immunogen: This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 1799753-84-6
Product: BAY-876
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.31 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3
Accession NO.: Q9BYJ1
Protein Ino: 27923803
Official Symbol: ALOXE3
Geneid: 59344
Background: ALOXE3 is a member of the lipoxygenase family, whichare catabolized by arachidonic acid-derived compounds. The encodedenzyme is a hydroperoxide isomerase that synthesizes a unique typeof epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoicacid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). Thisepoxy alcohol can activate the the nuclear receptor peroxisomeproliferator-activated receptor alpha (PPARalpha), which isimplicated in epidermal differentiation. Loss of function of theenzyme encoded by this gene results in ichthyosis, implicating thefunction of this gene in the differentiation of human skin.
PubMed ID:http://aac.asm.org/content/52/9/3040.abstract
