Product Name: AKTIP Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: For WB starting dilution is: 1:1000
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 33 kDa
Immunogen: This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.
Host Species: Rabbit
Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
Physical State: Liquid
CAS NO.: 20325-40-0
Product: o-Dianisidine (dihydrochloride)
Buffer: Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration: 0.5 mg/ml
Storage Conditions: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS
Accession NO.: Q9H8T0
Protein Ino: 54035954
Official Symbol: AKTIP
Geneid: 64400
Background: The mouse homolog of this gene produces fused toes andthymic hyperplasia in heterozygous mutant animals while homozygousmutants die in early development. This gene may play a role inapoptosis as these morphological abnormalities are caused byaltered patterns of programmed cell death. The protein encoded bythis gene is similar to the ubiquitin ligase domain of otherubiquitin-conjugating enzymes but lacks the conserved cysteineresidue that enables those enzymes to conjugate ubiquitin to thetarget protein. This protein interacts directly withserine/threonine kinase protein kinase B (PKB)/Akt and modulatesPKB activity by enhancing the phosphorylation of PKBs regulatorysites. Alternative splicing results in two transcript variantsencoding the same protein.
PubMed ID:http://aac.asm.org/content/52/8/2943.abstract
