Product Name: ADRM1 Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: ELISA, IHC-P, WB
Applications: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 – 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: Predicted: 45 kDa Observed: 48 kDa
Immunogen: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1.The immunogen is located within amino acids 210 – 260 of ADRM1.
Host Species: Rabbit
Purification: ADRM1 antibody is affinity chromatography purified via peptide column.
Physical State: Liquid
CAS NO.: 1599432-18-4
Product: Ibrutinib-biotin
Buffer: ADRM1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Conditions: ADRM1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: Adhesion regulating molecule 1, ARM1, Gp110, hRpn13, Proteasomal ubiquitin receptor ADRM1, Proteasome regulatory particle non-ATPase 13, Rpn13
Accession NO.: NP_783163
Protein Ino: 28373194
Official Symbol: ADRM1
Geneid: 11047
Background: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).
PubMed ID:http://aac.asm.org/content/52/5/1806.abstract
