Product Name: ADRA2B Antibody
Species Reactivity: Human
Tested Applications: WB
Applications: α-2B adrenergic receptor antibody can be used for the detection of α-2B adrenergic receptor by Western Blot.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 50 kDa (calculated)
Immunogen: 200-299
Host Species: Chicken
Purification: Immunoaffinity Purified
Physical State: Liquid
CAS NO.: 343306-79-6
Product: Sugammadex (sodium)
Buffer: Phosphate-Buffered Saline. No preservatives added.
Concentration: 1 mg/mL
Storage Conditions: ADRA2B antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ADRA2L1, ADRA2RL1, Alpha-2B adrenergic receptor, Alpha-2 adrenergic receptor subtype C2, Alpha-2B adrenoceptor, ADRA2L1, ADRARL1, ALPHA2BAR, alpha-2BAR, Alpha2B adrenergic receptor, Alpha-2B adrenoreceptor
Accession NO.: NP_000673.1
Protein Ino: 4501965
Official Symbol: ADRA2B
Geneid: 151
Background: FUNCTION: α-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. SUMMARY: α-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This protein is the α2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the α2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This protein contains no introns in either its coding or untranslated sequences.
PubMed ID:http://aac.asm.org/content/52/5/1862.abstract
