Product Name: ACVR2B Antibody
Species Reactivity: Dog, Human
Tested Applications: ELISA, WB
Applications: ACVR2B antibody can be used for detection of ACVR2B by ELISA at 1:312500. ACVR2B antibody can be used for detection of ACVR2B by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
User Note: Optimal dilutions for each application to be determined by the researcher.
Predicted Molecular Weight: 33 kDa, 58 kDa
Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ACVR2B.
Host Species: Rabbit
Purification: Antibody is purified by peptide affinity chromatography method.
Physical State: Lyophilized
CAS NO.: 932108-20-8
Product: RSV604 (R enantiomer)
Buffer: Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.
Concentration: 1 mg/ml
Storage Conditions: For short periods of storage (days) store at 4˚C. For longer periods of storage, store ACVR2B antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: ACVR2B, HTX4, ACTRIIB, ActR-IIB
Accession NO.: AAH96245
Protein Ino: 64653215
Official Symbol: ACVR2B
Geneid: 93
Background: Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
PubMed ID:http://aac.asm.org/content/52/3/1052.abstract
