Product Name: 4E BP1 (Ab 45) Antibody
Species Reactivity: Human, Mouse, Rat
Tested Applications: IF, IHC, WB
Applications: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
User Note:
Predicted Molecular Weight: 18 kDa
Immunogen: 4E-BP1 (Ab-45) antibody was raised against a peptide sequence around aa.43~47 (S-T-T-P-G) derived from Human 4E-BP1.
Host Species: Rabbit
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Physical State: Liquid
CAS NO.: 62304-98-7
Product: Thymalfasin
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Conditions: Store antibody at -20˚C for up to one year.
Clonality: Polyclonal
Conjugate: Unconjugated
Alternate Names: BP-1, 4EBP1, 4E-BP1, PHAS-I, FKHLA, EIF4EBP1, PHAS-1
Accession NO.: NP_004086.1
Protein Ino: 4758258
Official Symbol: EIF4EBP1
Geneid: 1978
Background: 4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
PubMed ID:http://aac.asm.org/content/51/11/4071.abstract
